DrugRepV Browse Page


DrugRepV browse page allows user to take a glance of the particular antiviral agent.Fields in the webpage is hylerlinked ot various external repositories like DrugBank, PubChem, Clinicaltrials.gov,and PubMed.User can explore the biological, Clinical, Chemical, and Structural details of every repurposed drug candidate.By clicking on the table header arrows, user can sort entries in ascending or descending order.


Total number of Records for Protease Assay are 53




DrugRepV_ID Antiviral Name
Drug type
Primary Indication
Secondary Indication
Strain
Pathways
Assay
Activity
Clinical Status
 References
DrugRepV_6349(2S)-6-amino-2-[(2S)-2-[(4-{[(5Z)-3-butyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl}phenyl)formamido]-5-carbamimidamidopentanamido]-N-[(1S)-1-carbamoylpentyl]hexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6350(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(4-{[(5Z)-3-cyclopentyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl}phenyl)formamido]pentanamido]-N-[(1S)-1-carbamoylpentyl]hexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6351(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(4-{[(5Z)-3-cyclohexyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl}phenyl)formamido]pentanamido]-N-[(1S)-1-carbamoylpentyl]hexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6352methyl 2-[(5Z)-5-[(4-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-1-carbamoylpentyl]carbamoyl}pentyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}phenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]hexanoate
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6353(2S)-6-amino-2-[(2S)-2-[(4-{[(5Z)-3-benzyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl}phenyl)formamido]-5-carbamimidamidopentanamido]-N-[(1S)-1-carbamoylpentyl]hexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6354(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(4-{[(5Z)-3-[(4-methylphenyl)methyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl}phenyl)formamido]pentanamido]-N-[(1S)-1-carbamoylpentyl]hexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6355(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(4-{[(5Z)-3-[(4-methoxyphenyl)methyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl}phenyl)formamido]pentanamido]-N-[(1S)-1-carbamoylpentyl]hexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6356(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(4-{[(5Z)-3-[(4-fluorophenyl)methyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl}phenyl)formamido]pentanamido]-N-[(1S)-1-carbamoylpentyl]hexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6357(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(4-{[(5Z)-3-[(4-chlorophenyl)methyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl}phenyl)formamido]pentanamido]-N-[(1S)-1-carbamoylpentyl]hexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6358(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(4-{[(5Z)-4-oxo-3-(2-phenylethyl)-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl}phenyl)formamido]pentanamido]-N-[(1S)-1-carbamoylpentyl]hexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6359(2S)-6-amino-2-[(2S)-2-[(4-{[(5Z)-3-butyl-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}phenyl)formamido]-5-carbamimidamidopentanamido]-N-[(1S)-1-carbamoylpentyl]hexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6360(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(4-{[(5Z)-3-cyclopentyl-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}phenyl)formamido]pentanamido]-N-[(1S)-1-carbamoylpentyl]hexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6361(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(4-{[(5Z)-3-cyclohexyl-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}phenyl)formamido]pentanamido]-N-[(1S)-1-carbamoylpentyl]hexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_63622-[(5Z)-5-[(4-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-1-carbamoylpentyl]carbamoyl}pentyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}phenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl acetate
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6363(2S)-6-amino-2-[(2S)-2-[(4-{[(5Z)-3-benzyl-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}phenyl)formamido]-5-carbamimidamidopentanamido]-N-[(1S)-1-carbamoylpentyl]hexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6364(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(4-{[(5Z)-3-[(4-methylphenyl)methyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}phenyl)formamido]pentanamido]-N-[(1S)-1-carbamoylpentyl]hexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6365(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(4-{[(5Z)-3-[(4-methoxyphenyl)methyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}phenyl)formamido]pentanamido]-N-[(1S)-1-carbamoylpentyl]hexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6366(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(4-{[(5Z)-3-[(4-fluorophenyl)methyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}phenyl)formamido]pentanamido]-N-[(1S)-1-carbamoylpentyl]hexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6367(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(4-{[(5Z)-3-[(4-chlorophenyl)methyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}phenyl)formamido]pentanamido]-N-[(1S)-1-carbamoylpentyl]hexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6368(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(4-{[(5Z)-2,4-dioxo-3-(2-phenylethyl)-1,3-thiazolidin-5-ylidene]methyl}phenyl)formamido]pentanamido]-N-[(1S)-1-carbamoylpentyl]hexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6369(2S)-N-[(5S,8S)-1-amino-11-carbamimidamido-6,7-dioxo-8-(phenylformamido)undecan-5-yl]-2-hydrazinylhexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6370(2S)-N-[(5S,8S)-1-amino-11-carbamimidamido-6,7-dioxo-8-[(thiophen-2-yl)formamido]undecan-5-yl]-2-hydrazinylhexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6371(2S)-N-[(5S,8S)-1-amino-11-carbamimidamido-8-({4-[(1E)-2-cyano-2-(cyclopropylcarbamoyl)eth-1-en-1-yl]phenyl}formamido)-6,7-dioxoundecan-5-yl]-2-hydrazinylhexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6372(2S)-N-[(5S,8S)-1-amino-11-carbamimidamido-8-({4-[(1E)-2-carbamoyleth-1-en-1-yl]phenyl}formamido)-6,7-dioxoundecan-5-yl]-2-hydrazinylhexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6373(2S)-N-[(5S,8S)-1-amino-11-carbamimidamido-6,7-dioxo-8-[(2E)-3-phenylprop-2-enamido]undecan-5-yl]-2-hydrazinylhexanamide
NA
NA
Dengue virus
NA
Pathway
Protease Assay
Decrease (50 %)
NA
24083834
DrugRepV_6458(3E)-N-tert-butyl-2-oxo-4-phenylbut-3-enamide
NA
NA
Dengue virus
NA
Pathway
Protease assay
Decrease (26.3 %)
NA
21641807
DrugRepV_6459(3E)-N-tert-butyl-3-methyl-2-oxo-4-phenylbut-3-enamide
NA
NA
Dengue virus
NA
Pathway
Protease assay
Decrease (25.6 %)
NA
21641807
DrugRepV_6460(3E)-N-tert-butyl-2-oxo-4-(thiophen-2-yl)but-3-enamide
NA
NA
Dengue virus
NA
Pathway
Protease assay
Decrease (27.6 %)
NA
21641807
DrugRepV_6461(3E)-N-tert-butyl-4-(4-methoxyphenyl)-2-oxobut-3-enamide
NA
NA
Dengue virus
NA
Pathway
Protease assay
Decrease (16.7 %)
NA
21641807
DrugRepV_6462(3E)-N-tert-butyl-4-(3,4-dimethoxyphenyl)-2-oxobut-3-enamide
NA
NA
Dengue virus
NA
Pathway
Protease assay
Decrease (36.1 %)
NA
21641807
DrugRepV_6463(3E)-N-tert-butyl-4-(4-hydroxyphenyl)-2-oxobut-3-enamide
NA
NA
Dengue virus
NA
Pathway
Protease assay
Decrease (37.6 %)
NA
21641807
DrugRepV_6464(3E)-4-(4-aminophenyl)-N-tert-butyl-2-oxobut-3-enamide
NA
NA
Dengue virus
NA
Pathway
Protease assay
Decrease (40.6 %)
NA
21641807
DrugRepV_6465(3E)-N-tert-butyl-4-(4-chlorophenyl)-2-oxobut-3-enamide
NA
NA
Dengue virus
NA
Pathway
Protease assay
Decrease (15.9 %)
NA
21641807
DrugRepV_6466(3E)-N-tert-butyl-4-(1H-indol-3-yl)-2-oxobut-3-enamide
NA
NA
Dengue virus
NA
Pathway
Protease assay
Decrease (39.1 %)
NA
21641807
DrugRepV_6467(3E)-N-tert-butyl-4-[4-(dimethylamino)phenyl]-2-oxobut-3-enamide
NA
NA
Dengue virus
NA
Pathway
Protease assay
Decrease (13.8 %)
NA
21641807
DrugRepV_6468(3E)-N-cyclopropyl-2-oxo-4-phenylbut-3-enamide
NA
NA
Dengue virus
NA
Pathway
Protease assay
Decrease (31.2 %)
NA
21641807
DrugRepV_64692-[(3E)-2-oxo-4-phenylbut-3-enamido]ethyl acetate
NA
NA
Dengue virus
NA
Pathway
Protease assay
Decrease (35.8 %)
NA
21641807
DrugRepV_6470(3E)-2-oxo-4-phenyl-N-(1-phenylethyl)but-3-enamide
NA
NA
Dengue virus
NA
Pathway
Protease assay
Decrease (0 %)
NA
21641807
DrugRepV_6471methyl 3-hydroxy-2-[(3E)-2-oxo-4-phenylbut-3-enamido]propanoate
NA
NA
Dengue virus
NA
Pathway
Protease assay
Decrease (35.1 %)
NA
21641807
DrugRepV_7299(3E)-N-tert-butyl-2-oxo-4-phenylbut-3-enamide
NA
NA
West Nile virus
NA
Pathway
Protease assay
Decrease (20 %)
NA
21641807
DrugRepV_7300(3E)-N-tert-butyl-3-methyl-2-oxo-4-phenylbut-3-enamide
NA
NA
West Nile virus
NA
Pathway
Protease assay
Decrease (0 %)
NA
21641807
DrugRepV_7301(3E)-N-tert-butyl-2-oxo-4-(thiophen-2-yl)but-3-enamide
NA
NA
West Nile virus
NA
Pathway
Protease assay
Decrease (20.3 %)
NA
21641807
DrugRepV_7302(3E)-N-tert-butyl-4-(4-methoxyphenyl)-2-oxobut-3-enamide
NA
NA
West Nile virus
NA
Pathway
Protease assay
Decrease (27.3 %)
NA
21641807
DrugRepV_7303(3E)-N-tert-butyl-4-(3,4-dimethoxyphenyl)-2-oxobut-3-enamide
NA
NA
West Nile virus
NA
Pathway
Protease assay
Decrease (31 %)
NA
21641807
DrugRepV_7304(3E)-N-tert-butyl-4-(4-hydroxyphenyl)-2-oxobut-3-enamide
NA
NA
West Nile virus
NA
Pathway
Protease assay
Decrease (31.4 %)
NA
21641807
DrugRepV_7305(3E)-4-(4-aminophenyl)-N-tert-butyl-2-oxobut-3-enamide
NA
NA
West Nile virus
NA
Pathway
Protease assay
Decrease (39.5 %)
NA
21641807
DrugRepV_7306(3E)-N-tert-butyl-4-(4-chlorophenyl)-2-oxobut-3-enamide
NA
NA
West Nile virus
NA
Pathway
Protease assay
Decrease (6.3 %)
NA
21641807
DrugRepV_7307(3E)-N-tert-butyl-4-(1H-indol-3-yl)-2-oxobut-3-enamide
NA
NA
West Nile virus
NA
Pathway
Protease assay
Decrease (40.6 %)
NA
21641807
DrugRepV_7308(3E)-N-tert-butyl-4-[4-(dimethylamino)phenyl]-2-oxobut-3-enamide
NA
NA
West Nile virus
NA
Pathway
Protease assay
Decrease (33.9 %)
NA
21641807
DrugRepV_7309(3E)-N-cyclopropyl-2-oxo-4-phenylbut-3-enamide
NA
NA
West Nile virus
NA
Pathway
Protease assay
Decrease (20 %)
NA
21641807
DrugRepV_73102-[(3E)-2-oxo-4-phenylbut-3-enamido]ethyl acetate
NA
NA
West Nile virus
NA
Pathway
Protease assay
Decrease (29.8 %)
NA
21641807
DrugRepV_7311(3E)-2-oxo-4-phenyl-N-(1-phenylethyl)but-3-enamide
NA
NA
West Nile virus
NA
Pathway
Protease assay
Decrease (12.2 %)
NA
21641807
DrugRepV_7312methyl 3-hydroxy-2-[(3E)-2-oxo-4-phenylbut-3-enamido]propanoate
NA
NA
West Nile virus
NA
Pathway
Protease assay
Decrease (27.5 %)
NA
21641807